Pharmacokinetic models attempt to describe the relationship between dose and plasma concentration with respect to time. A pharmacokinetic model is a mathematical model that can be used to predict the blood concentration profile of a drug after a bolus dose or after an infusion of varying duration. These models are typically derived form measuring arterial or venous plasma concentrations after a bolus or infusion in a group of volunteers, using standardised statistical approaches and computer software models.
Mathematical models generate some pharmacokinetic parameters such as volume of distribution and clearance. These can be used to calculate the loading dose and rate of infusion necessary to maintain a steady-state plasma concentration at equilibrium.
Since it has been recognised that pharmacokinetics of most anaesthetic agents conform best to a three compartmental model, numerous algorithms for targeting blood and effect site concentrations have been published and several automated systems have been developed.
Post time: Nov-05-2024